IMMUNE CHECKPOINT INHIBITOR PD-1 PATHWAY IS DOWN-REGULATED IN SYNOVIUM AT VARIOUS STAGES OF RHEUMATOID ARTHRITIS DISEASE PROGRESSION.

Immune checkpoint blockade with therapeutic anti-cytotoxic T lymphocyte-associated antigen (CTLA)-4 (Ipilimumab) and anti-programmed death (PD)-1 (Nivolumab and Pembrolizumab) antibodies alone or in combination has shown remarkable efficacy in multiple cancer types, concomitant with immune-related adverse events, including arthralgia and inflammato

In order to quantitatively study the influence of tailings fine content on the properties of cemented paste backfill (CPB) and further understand the mechanism of tailings fine content acting, the concept of packing balance bikes density was introduced in this study.The packing density of each tailings sample was measured by the wet packing method